Novel catalytic static mixers developed using safe hydrogen

A novel type of catalytic static mixer with a rectangular cross-section coated with Pd/Al2O3 were developed by Dr. René Lebl and the team working under Prof. Oliver Kappe as part of the CCFLOW Project in combination with the team from the Centre for Industrial Flow Chemistry at CSIRO Manufacturing in Australia.

Using a Miprowa Lab Reactor from Ehrfeld Mikrotechnik and the internationally award-winning H-Genie® Smart Hydrogen Generator, the mixers showed excellent catalytic performance for continuous flow hydrogenation of nitroaromatics. The heterogeneous catalyst is highly stable with no loss of catalytic performance observed after long periods of activity and ICP-MS measurements determined that essentially no Pd or Al leached from the reactor. The process developed has been showcased for the synthesis of the key intermediate of the medicine tizanidine. The process was operated for 8 h, yielding 96% of the desired product after simple removal of the solvent.

The research group utilized the H-Genie® to provide a safe and continuous stream of hydrogen for both the optimization and material production parts of the project showcasing its versatility and accuracy, turning their Miprowa Lab Reactor into a hydrogenation system. All experimental data was exported from the H-Genie® via USB.

The full, free access paper can be found here.


Hydrogen Utilization

Hydrogen is one of the most useful and popular reagents in a chemistry lab. However, due to its volatile nature, you must know how to use it carefully. View our recorded educational webinar with HeidolphNA, where we discuss the safety, sources, and industrial applications of hydrogen in chemistry, as well as the state of the art technology to accessing it in the lab, including:

  • Applications of hydrogen gas
  • Hydrogen gas sources
  • Uses of hydrogen gas
  • Hydrogen for GC/LC
  • Hydrogenation: What is it?
  • Lab equipment for hydrogenation
  • Hydrogenation reactions
  • How to handle hydrogen safely
  • Using an autoclave with a hydrogen generator
  • Smart hydrogenation for technology enabled library snythesis
  • Performing hydrogenation reactions in flow
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Hydrogen Safety in Chemistry

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In this white paper, we will explore the uses of hydrogen within the chemistry world, the hazards and risks associated with hydrogen, and methods we can use to mitigate these risks. We hope that this concise paper will give you a quick overview of what must be considered when using hydrogen at your facility.