A novel type of catalytic static mixer with a rectangular cross-section coated with Pd/Al2O3 were developed by Dr. René Lebl and the team working under Prof. Oliver Kappe as part of the CCFLOW Project in combination with the team from the Centre for Industrial Flow Chemistry at CSIRO Manufacturing in Australia.
Using a Miprowa Lab Reactor from Ehrfeld Mikrotechnik and the internationally award-winning H-Genie® Smart Hydrogen Generator, the mixers showed excellent catalytic performance for continuous flow hydrogenation of nitroaromatics. The heterogeneous catalyst is highly stable with no loss of catalytic performance observed after long periods of activity and ICP-MS measurements determined that essentially no Pd or Al leached from the reactor. The process developed has been showcased for the synthesis of the key intermediate of the medicine tizanidine. The process was operated for 8 h, yielding 96% of the desired product after simple removal of the solvent.
The research group utilized the H-Genie® to provide a safe and continuous stream of hydrogen for both the optimization and material production parts of the project showcasing its versatility and accuracy, turning their Miprowa Lab Reactor into a hydrogenation system. All experimental data was exported from the H-Genie® via USB.
The full, free access paper can be found here.